Phosphatidylserine (PS) is a phospholipid that plays several important roles in human health. Found naturally in foods like fatty fish and soy, it is also available as a dietary supplement. In recent decades, research on PS has revealed promising evidence that it may benefit brain function and cognition in older adults. This article explores what PS is, the research behind its potential effects on the brain, and how it might be incorporated into a brain-healthy lifestyle.

What is Phosphatidylserine?

PS is a type of fat molecule known as a phospholipid. It is found naturally in cell membranes throughout the body, particularly in high concentrations in the brain. PS helps maintain the structural integrity of cell membranes and influences the flow of messages between cells.

In the brain, Phosphatidylserine is highly concentrated in regions important for memory and cognition like the hippocampus. Research shows it plays a key role in neural signaling pathways and may help support brain cell growth and connectivity as we age.

PS is obtained through dietary sources like meat, fish, eggs, and soy or as a supplement. As humans age, PS levels naturally decline in the brain, which some researchers believe may contribute to cognitive changes associated with aging. Supplementing with additional PS is theorized to help make up for this decline.

Research on PS and Brain Function

Several clinical trials have investigated PS supplements for their potential to support brain health in older adults:

- Memory and Learning: Some studies found PS improved short-term memory recall and learning ability in older participants. Effects were seen at daily doses of 100-300mg of PS taken over several months.

- Mood and Behavior: Supplementation appeared to have positive impacts on mood, behavior, motivation, and feelings of well-being in aging populations.

- Brain Imaging: Imaging studies found PS correlated with increased brain activity in areas associated with memory formation. It also appeared to stimulate blood flow and oxygen metabolism in the brain.

- Alzheimer's Disease: Early research suggests PS may help slow cognitive decline in mild Alzheimer's, though more research is still needed. It does not appear effective for moderate to severe cases.


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