While Duratia is generally safe and effective for short-term use in managing PE, the long-term safety and efficacy of continuous or frequent use have not been extensively studied. Some concerns have been raised about the potential for tolerance to develop with long-term use, leading to reduced effectiveness over time. Therefore, it's generally recommended to use Duratia on an as-needed basis and to discuss any concerns about long-term use with a healthcare provider. https://www.flatmeds.com/product/duratia-30-mg/